One thing many designers and programmers alike struggle with are who their circle/users are and what they want. The problem, if it is a problem, with bootstrap is that it makes everything look the same. It's both smart and lazy from a web-dev's pov.
At first I was a bit annoyed and confused but then I actually liked it, the more I had to get creative with CSS because although you can reinterpret a subreddit in 1000 different ways, they all "feel" the same.
I mean, I basically just gave an elevator pitch for CSS but I suppose my point is that Reddit works well as it is. You might have to do a bit of thinking outside the box but some nice designs are possible.
If you need anything more than that, chances are your design is a bit too over the top and should be simplified.