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East 1 is indeed the oldest and has the most non-standard configuration of the bunch (besides China, of course). I definitely would recommend east 2 or west 2 for any new deployments.

I'd guess it's the oldest data centre so more prone to failures, but that's pure speculation.

Isn't it the cheapest region to use? Probably sees more use because of it.

us-west-2 (Oregon) and us-east-2 (Ohio) are the same price as us-east-1 (Virginia). At least that's true for most resources, I didn't check the full price list.

I don't know about Ohio since I don't use it, but we've had far fewer problems in us-west-2 than in us-east-1

If I have a single-region service, I always put it in us-west-2. It's super reliable, and gets updates after us-east-1 and us-west-1, which means all the kinks are out before they hit us-west-2.

On days like today, I without fail get a message from my friend who works at a shop where everything is in us-east-1 (multi-AZs) about how much he hates me for avoiding east like the plague.