I got some good advice in 500 a few years ago when trying to raise a Series A. We were getting the "location" excuse over and over. It usually went something like, "we love what you are doing, and we would probably invest in you, but your location is a non-starter for us." The truth, as was illuminated to me during, is that they just aren't interested. If you were a compelling enough business for the investor, your location would not be a factor. If you can prove that you are succeeding in your location, then the location obviously isn't an issue. Too many investors saw our location as an easy out, and it took a while to understand that. We had way too much hand-wringing about upending our families and moving to the Valley to try to secure investment, when we should have just been looking inward at our own shortcomings.