Except in the case of opioids, government and regular ARE the problem. If they were legal and available through a regulated supply, most of the OD's would never happen. They happen because someone gets a dose of the drug that's 10-100 times stronger than the one they had yesterday.
That's no different than people going blind/dying from wood alcohol during prohibition.
The solution is to legalize and regulate, but I'm not holding my breath.