Modern nutritional science is also showing that the way food is digested and metabolized in the body is strongly influenced by a complex hormonal interchange -- and whether organs like the liver or the gut are predominantly responsible for macronutrient metabolism has a significant effect on, for lack of a better word, "effective calorie counts" in foods. The macronutrient composition of what we eat clearly affects our hormonal reaction, which clearly affects feelings of hunger and satiety. To ignore these feedback loops in favor of strict energy-deficit reductionism is a bit like saying that anyone not programming in binary is wasting his or her time.