I'm pretty sure it's never illegal to have a drug in your system (besides something secondary like a DUI). It's only possession that's illegal.
E.g., with alcohol, the “in the blood is illegal” rule would criminalize auto-brewery syndrome occuring in those legally denied alcohol (e.g., due to age), while the “in the blood is admissible as evidence of use” would not, though those with the syndrome might need to present evidence of it to avoid charges.