I'm also hoping for node.js-like development in Clojure, it seems like as a Lisp, that style of development is well suited for it. What would be great is for someone to use JNI with libevent to create a nice, fast event driven server for Clojure/Java.

Edit: I forget, does java.nio already use kqueue/epoll and friends? If so then Netty should do the trick as it uses java.nio.