Brian from Backblaze here. I don't have any more info than you have, but some of us assume it is a form of the "IT Tax". Basically anything for "businesses" or "datacenters" the sellers charge (unreasonably) more than if it is a product for "consumers". Only a tiny number of consumers ever buy a 20 pack of internal hard drives. Thus they are given the "business tax" pricing increase.
The cost of a USB enclosure is about $2. So if the IT markup is larger than $2 the USB enclosure version, you'll see the same internal drive wrapped in a USB enclosure for less. Stupid? Yes.