Would it then become important for that business to give these minds that would not make them feel trapped and caged? Wouldn't the quality of results be hampered if lots of suffering were to occur? Could the mind at some point become useless since it would be drowned in depressive, cyclical, and often illogical thought? That, too, would create a research point, but would be pretty inhumane and I would hope an ethics oversight panel would not allow such states to exist.
So many questions surround this... If the body is dead, but the brain is still active of reasonable thought and to that end communication, who decides it's fate? Does a mind deteriorate once there is no outside stimuli of the senses?
Not that I would agree to be in this state, but man there would be huge fields of research to do.