For example, if you suddenly require 5000 c/day, you cannot simply eat more pizza, MT Dew, etc. You have to eat 5000 c/day of nutrient rich food. Your muscles do not only require calories. This is actually very hard to do (imagine how much actual food volume you have to process)!
You also need many more macronutrients to keep things going (all that extra food needs to be processed), and clean (significantly more waste byproducts produced).
Your cardiovascular system needs to grow in conjunction with the extra muscle -- it must keep up. As does your skeletal (bones, ligaments/tendons).