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I don't know if this is a hard/cold way of looking at things, but I want a bang for my back in donating to charity. I've (almost) exclusively give to malaria foundations.

Even if you don't want to give, set your Amazon to smile.amazon and it will donate a very small portion of your purchases to the charity of your choice. It may add up to $50-$100 in money given on your behalf over time.

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This is basically what the Gates Foundation does. The primarily focus on infectious disease and malaria is a big one (along with HIV, TB and others). They also dabble in charter schools and some other business, but the goal is always bang for buck.

https://www.effectivealtruism.org/ is substantially about bang for your buck.

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