- timing chain should be replaced at 100K. Should do the water pump at the same time. $800-$1000.
- starter motor (typically the brushes wear out). $300.
- engine mounts.
- CV joints.
- suspension bushings, possibly shock absorbers, wheel bearings too.
- pneumatic door lifts.
Then you just start to run into random problems: dashboard lights go out and are too expensive to replace, electric windows or door locks start to fail, steering develops a strange wobble that comes and goes and 3 different mechanics can't figure out. Etc.
I just sold my 2003 Odyssey (that I had bought new and maintained it well) with 230K on it. I'm glad to not be dealing with it anymore.
I still own a 98 Cherokee XJ which is built like a tank but still has its weaknesses. An electric door lock is failing but a replacement part is no longer made, so I have to find a used replacement or adapt a part from a newer vehicle. That sort of stuff.
If you're willing to deal with it great, but there's definitely a large tradeoff there.
There's also safety issues. My new cars have collision detection, lane keep assist, air bags all the way around, etc. I'm happier having my family in vehicles with these options.
It's expensive on gas (12-13mpg), but cheap to insure.
Not even an airbag.