Ain't no way I'm listening to mixes on YT when they put brickwall-compressed ads cutting in on un-normalized audio every 10 minutes. It's a non-starter; when I see those little yellow dots I hit the back button.
Have you used YouTube Red / the YouTube music app?
God no. The only way I'll consider paying YT a single red cent for anything they make is if I can permanently turn off annotations on videos, and I haven't been able to find anything that indicates a yes or no to that question, so I have to assume their stance is "GFY."
You can though. I've had them turned off for too long a time to remember what the setting was though.