If you mean in the frontend, AngularJS was going in that direction. Then react came along and the angular developers decided to copy it, in a different language and with even more boilerplate.

I believe nowadays it's ember the one that comes with batteries included, but I haven't used it nor read a lot about it so don't quote me on that.

If you meant the backend, the only one I always hear about is express, but I'm not sure about that one either.

Sails.js is a fill-stack JavaScript framework with similar scope to Django, such as:

- MVC - routing - templating (though, swappable) - ORM

As for maturity, Sails.js has been under active development for around 5 years, with a 1.0 release candidate available.

http://sailsjs.com/