Before bitcoin, an online business would be taking a huge risk if it accepted a credit card payment from someone in Latvia. The fraud rate on such payments is probably 50%. With bitcoin, it's safe and fast. I own such a business (a VPS hosting company) and Bitcoin really has been a great solution for us.
Before bitcoin, a legal pot shop would have to deal with cash because no bank would give it an account. Having all this cash around creates a danger for the employees, not to mention the armored car drivers. Bitcoin is a tool that can be used to solve the problem.