You can use webpack with Angular. RxJs is a great addition that will eventually be removed when Observables become implemented in JS. The declarative style of templates are different than JSX, but are not hard to deal with in practice. Native script allows for mobile dev, although I don't personally use it.
Before I switched to Angular, I preferred React. Now that I use this framework approach, I am much happier and have more faith that my code base will be consistent. I read somewhere that google used Angular for adsense so I think it is good enough for production use for us.