I use and love Google Reader. I use the List mode (as opposed to Expanded) and my work flow is the same whether I'm at my desktop, iPhone, iPad, or Blackberry.

A handful of feeds I insist on reading everything, which means I hit J-J-J-J to get through them all. But most I merely skim the unread titles for things that look interesting, and when I'm done I hit Mark As Read to clean up the rest.

I like how I can do this at feed-level, category-level, or with all unread items at once.

And if I'm mobile and I want to see something from my desktop, I star it.

Admittedly, the last time I considered using a thick-client reader was way, way back in 2004 when I was still Windows-only, and I wasn't happy with anything I saw. I've used Google Reader since it was released in 2005, and I've had no reason to use anything else.