Remember NT was always designed to be cross platform - it shipped on x86, PPC, MIPS and Alpha originally. I ran SQL Server on Alpha for a while. Good times.
The Sunway line of processors developed by the Chinese military are rumored to use a modernized version of the Alpha instruction set (unauthorized obviously): https://en.wikipedia.org/wiki/Sunway
It those went to Intel... Well... It'll be fun to watch the fireworks.
I wonder if WoW64 had to be modified to support having two architectures.
Though they maybe planned ahead: it's "Program Files (x86)", not "Program Files (32-bit)" :)
MMX/SSE/SSE2/SSE3/SSSE3/SSE4.1/SSE4.2/POPCNT/AESNI/CTMUL
It was somewhat outlined in this channel 9 video: https://channel9.msdn.com/Events/Build/2017/P4171