One thing that bothers me a bit is that it is hard to tell how decentralized these technologies really are. Especially when you go into direction where commodity hardware becomes useless and you need specialty equipment to do meaningful mining, there's a risk that the power falls into few hands.
This is probably not an issue for bitcoin, where the incentive to cheat would be to just gain monetary profits. In some other blockchains, serving different purposes things might be different. Governments with their deep pockets might be interested in building up capacity to be able to perform covert ops.
[1] https://bitcoinwisdom.com/bitcoin/difficulty [2] https://www.bitcoinmining.com/bitcoin-mining-hardware/