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"Systematic brain delivery", is your lab simply jacking up L-DOPA or L-tyrosine in the substantia nigra? Also by massive information is your lab doing machine learning directly on fMRI output or do you also run statistical analysis on all published Parkinson's research in general? Would it be possible for you to run a meta-analysis on Parkinson's studies involving alpha-7 nicotinic receptor agonists?

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Our lab's main focus is targeted delivery to the brain which can be used to treat a lot of neurodegenerative diseases. Specifically for Parkinson's, we infuse an AADC vector into the putamen to break down L-DOPA into Dopamine. Further down the road, we are looking at using GDNF to save dying neurons that convert L-DOPA into Dopamine. The specifics are here: http://neurosurgery.ucsf.edu/bankiewicz/parkinsons.html

Regarding massive information, I analyze a lot of the data we generate in order to optimize our delivery platform. Since there are few labs that do this kind of work, all the data I work with comes from us.

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