Threadripper has half the memory channels and half the PCIe lanes.
EPYC is available with up to twice the cores.
The main advantage I see for Threadripper is that at 16 cores EPYC will have half the cores disabled, so for problems that fit in L2 you lose some performance from the reduced L2 sharing. That and it should be priced better than server chips, with I suspect the 12 - 14 core being the sweet spot.
Based on leaks I think Threadripper might boost a few 100 MHz higher, with base clock up to 3.6GHz.