Issue 10 is my all-time favorite:

> The polyglot file pocorgtfo10.pdf is valid as a PDF, as a ZIP file, and as an LSMV recording of a Tool Assisted Speedrun (TAS) that exploits Pokémon Red in a Super GameBoy on a Super NES. The result of the exploit is a chat room that plays the text of PoC‖GTFO 10:3. Run it in LSNES with the Gambatte plugin, the Japanese version of the Super Game Boy ROM and the USA/Europe version of Pokémon Red.