I have to remember how to start postgres, the erb command to make rails work, figure out how my upgrade to bash subtly broke virtualenvwrapper, make sure I didn't accidentally leave anything open in vim in some random window or go through the whining about vim swap files, and dump/restore all the state spread through 20+ browser windows, probably 30+ bash instances, and a couple repls. etc. It's really fucking annoying.
Another thing that ate 3 hours of my life recently: post reboot, zoom.us, which previously worked flawlessly, no longer works. I of course discover this as a meeting is starting.