I have enabled proper 2FA on my Google account with U2F, but I haven't disabled everything else yet because I only have one token, and I still need something like TOTP for stuff that uses Google accounts, but doesn't support U2F.
As a closely related remark, I wish U2F would just get popular enough, it's pretty convenient, isn't vulnerable against the kind of attack SMS-based 2FA is, and protects against phishing. But almost nobody outside Google supports it, and OS/Application support is rather incomplete or requires additional setup.