What I meant by "No framework" was that there is no "Framework API" to implement. Cell itself is a framework, so I agree that frameworks are for greater good.
As for your question on how it scales, I don't see a reason why it shouldn't scale. In fact I think this approach is more scalable than any existing centralized approaches to building web apps because you can create complexity out of simplicity.
p.s. The "No framework" part is just one of the benefits that arise as a side effect of Cell's decentralized architecture. I did my best to explain why I built this on the homepage. I know it's long but I hope you take a look at it once more, it's worth a read even if you don't use the framework because Cell does bring something new to the table. Hope this makes sense!