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House is Sherlock Holmes.

Yep, House -> Holmes; Wilson -> Watson.

Cocaine -> Vicodin

Holmes was also quite into opiates himself - I seem to remember a Persian slipper that housed his heroin stash, and some incidents of opium smoking.

wouldn't that be Holmes -> House?

Sherlock Holmes has been around since around 1891; predating Gregory House by about 113 years.

Right so House is later than the Holmes.

the arrow of time in Western cultures moves from left to right.