The only thing that bothers me about the all notebook route ( and trust me, I'd really like to do this) is that their disk drives are still butt-slow. I do a huge amount of creating and modifying virtual machines for deploy. The copy/clone operation that takes my disk array of cheap desktop sata drives 5 minutes to do takes my macbook pro nearly half an hour. All the cores and ram helps too. Those who work with large video, audio and graphics files probable have similar experiences.

Lets just say that there will be less reasons to have a big, boxy computer on one's desk...