I would not. That's incidentally depending on non-zero numbers to become True, and zero to become False. I would prefer to think of the operation as "is x modded by 2 equal to zero?" rather than "does x modded by 2 become true when negated?"
I suspect that it will be easier for core Python developers rather that general Python programmers because they will be more intimately familiar with the conversion rules. I would be more comfortable with such a construct in C or C++, because I am more confident in those conversion rules. But, even though Python's are quite similar, I had to check myself before making my comment, because I knew they were similar, but I was not sure what they were. The situation in the stackoverflow comment is also not quite the same: asking a question about the relationship of numbers (is x modded by 2 equal to zero) is a special case of using integers in a boolean context. Saying it's Pythonic to use an integer in a boolean context does not necessarily mean it's best to always do so.
I don't feel that there is anything incidental about that. Integer zero is logically false and any other integer is logically true.