Doubtful. Take Two have released a fair number of Linux games already, at least from 2K's catalog - Borderlands, Bioshock Infinite, XCOM, etc. I guess much of this is down to the individual developers rather than the parent company, but it is at least evidence that Take Two has no inherent issue with their games being on Linux.

Not to mention the game being in Unity, already running on Linux, and I assume a higher than average proportion of Linux players (I have no numbers for this, but I'd be surprised if this wasn't the case), I can't any reason why they'd want to drop support.

Isn't Linux becoming more and more compatible with modern games/development?