- Killing MSFT would do a lot of short-term economic damage, but the new innovation that happens to fill its place would probably be an easy net boon. Linux would be a fast replacement, and it would probably force that ecosystem to blossom. As someone who doesn't use any MSFT products (I have no need for them), I wouldn't personally suffer at all.
- Amazon is the center of online commerce, but I think it's already a fat, complacent company. Their infrastructure is famously good, but the purchasing experience is crap. Finding what you want is much harder than it should be for an online experience, and the recommendations are laughably bad. What takes its place would necessarily be much better.
- Apple's products are still a force of pressure on the market to innovate, though I suspect that will not be true for much longer. Their latest products are less clearly better than the competition, and they've made some bizarre design blunders. My next phone/laptop will likely not be Apple, so once their innovation dries up, seeing them disappear probably wouldn't make much of a difference in my life.
- Google and Gmail are still unparalleled. One could imagine something better than Gmail, but Google search is so core and effortless it's hard to picture what an improvement would look like. Deleting google would break the internet.