I sometimes use Facebook to talk to non-close friends, although I do use Whatsapp daily, so I guess that counts too.
All in all, I don't think it's impossible to escape at least one of them.
Except apparently, Google, Facebook and Microsoft [1]. If you have any apps installed then probably AWS also indirectly or maybe even fulfillment that you don't know is coming from one of their FCs
That's not even mentioning that you're tracked across the world by them even if you don't go there directly.
I think the only person that doesn't use any of those and is still on the internet directly is RMS [2]
The idea that you can actually live in modern society and not touch one of the big 5 is misguided.
[1]https://duck.co/forum/thread/4350/did-you-know-that-duckduck...
You guess Android counts, well of course it does.
My contacts and calendar are synchronized with a webdav server called radicale that I self-host. I also self-host my own mail with a postfix+dovecot setup.
Really, the last remaining google service I use is google search. And I've hit a brick wall there. The alternatives just suck too much. DDG's search result has been consistently terrible, and while I still hope qwant will one day turn into a great product, right now the search result are still significantly poorer than google's.
Android doesn't count with a setup similar to mine, because it's all open source and doesn't communicate with google outside of expectations :).