- environmental degradation is based on two exponential growth trends: human population and per-capita consumption (driven by economic growth). Solving either could be, literally, a save the world scenario. The first is easiest technically, (healthcare, non-coercive birth control, education, economic opportunity for women) but a political minefield. (yes, population is still growing exponentially)
- dealing with climate change. At a minimum, this means figuring out how to handle a significant rise in sea level in the next 100 years. Walls? Relocation? We need to think about response now, more so than avoidance.
- actually doing geo-engineering to prevent/reverse the greenhouse effect
- preventing a nuclear war
- preventing a large asteroid collision
- dealing with large-scale disruption of employment (for example retail continues to be hammered by online stores, self-driving trucks, etc.) Build a better Mechanical Turk might be a useful strategy.
Obviously some of these are low-probability short-term events, but they have very high costs. In a sense, you would be taking advantage of people's tendency to systematically under-invest in problems of that kind.