I, too, wanted a Unicorn Job of this sort: http://pgbovine.net/unicorn-jobs.htm

After some trial and error bouncing around in industry/postdoc/etc., I've found that being a PI in a field where I have to raise relatively small amounts of money (compared to Big Science labs) to be the best balance for me at this point. I agree with Fomite that unless I magically get amazing at grant-writing, there's no way that I could afford to sustain full-time staff ... I don't envision myself going down this path since I want to minimize time spent writing grants and maximize my research/teaching/service time.