Heroin, LSD, etc. use really doesn't affect me. I don't care if people use it, and don't want the government to waste money fighting it or whatever they do. I don't care if people manufacture it, as long as they follow all the usual regulations for dangerous chemical plants (like, don't have one in an apartment building). Anyone should be able to grow weed wherever they'd grow lettuce or whatever, no danger there. I also don't care if they sell it, as long as they collect sales tax and pay income tax, so that we can pay for welfare and healthcare and such.

Let's have a war on smoking instead. I live in New York, and people think it's perfectly acceptable to light a cigarette while walking down the sidewalk and spew their fumes all over everyone walking behind them. Let's punish that like we'd punish them for punching random people on the sidewalk. Hey, if someone hits me and they're not a trained boxer, I'll probably feel fine a few minutes later, but that cancer smoke builds up over time.

Then we can move on to exhaust-producing vehicles, and so on...