2.5 billion barrels is about 300,000,000,000 liters, which is 300,000,000 cubic meters, which is about half a cubic km.
If any significant fraction of that volume is removed, it seems likely to me that there will be cave-ins around the bubble. If those cave-ins are big enough, they could create cracks that would cause more leaks to come out. Alternately they could produce places for oil to go that won't leak out the current hole. Or they could widen the current hole.
Of course long before that point we should have relief wells. But the challenge there is that the wells are hard to put in and the existing leak lends an element of instability. The last thing anyone wants is to have further accidents on the relief wells. But when you're hurrying under difficult circumstances, accidents cannot be ruled out.