A lot of it comes down to access to information and speed. All the major traders and quants have access to what effectively boil down to mailing lists (that their companies pay top dollar for) that have the best analysts in the world producing in-depth analysis on various topics[0]. Also, many/most have access to a Bloomberg terminal[1] to get the Bloomberg new feeds and the AIM clone, which costs $25,000/year/person.
This is why amateur day-trading is silly. You're not competing in a level playing field- they know more than you do.
[0]http://www.investopedia.com/articles/analyst/03/031803.asp [1]https://en.wikipedia.org/wiki/Bloomberg_Terminal
Disclaimer, I work at Quantopian.
>A former student of Mr. Fama, Cliff Asness, founder of quantitative hedge-fund manager AQR Capital Management, said he tries to avoid being caught out by false findings by trading on anomalies he can explain, economically or through investor behavior. To assess whether the market anomalies will continue, he looks for ones which carried on after being identified, can be seen in other markets or asset classes, and where minor changes to how they are defined don’t much affect the result. These include most famously value, momentum and corporate quality, among others.
https://www.wsj.com/articles/an-algorithm-an-etf-and-an-acad...
Then simulate rolling optimisation and trading to see what returns could have been achieved with knowledge only available at the time.