On the other hand, "keep up with JS" is something of a misnomer here. It's not javascript that's moving super-fast, it's the web ecosystem (plus the node one, in parallel). It's moving fast because new ideas are evolving at speed (functional-reactive approaches, new ways to think about mixins vs multiple inheritance, etc), and those ideas lead to new framework architectures gaining popularity as they exploit these new ways of thinking about organizing data flow through a complicated system.
Couple that with some baseline things that aren't changing here - you're still going to have to interact with the DOM, you aren't going to magically get re-entrant multithreading, and the event model isn't changing. There's still going to be a lot about web programming that feels different from systems programming, and things are still going to move quickly. Probably even more quickly (but I'm not certain about that - I imagine one major reason JS shifts quickly is that it has so many programmers working with it, if the population fragments there will probably be a number of slow-moving communities that neither shift often nor take advantage of new features, which feels like the kind of neophile - neophobe split that's already apparent in different areas of programming).
So: I am not convinced that a (say) rust or go compiler to WASM will suddenly make front-end programming feel like systems programming. It'll be a new language, sure, but there's a lot more to web development and the (reasonable) complaints people have about a shifting landscape than just javascript and its funky definition of OO and triple equals sign.