For power users it's annoying and disruptive. For users that might benefit the most from it they quickly learn to press ok always whenever they are prompted for something, no matter what it's asking.
In my opinion, an ideal OS would have absolutly no confirmation dialogs what so ever, but instead it would have unlimited systemwide undo for any action. Look at Gmail vs Microsoft 360 webmail. One is a pleasure to use, the other a pain in the but. Some of that difference comes from dialogs and extra steps in 360 where GMail instead lets you undo.
Add powerful application isolation like in iOS, but make it as simple for the user to pass data between programs as it conceptually is to pipe text from one command to another in Unix, except that you shouldn't have to set up the pipeline first, instead you open a program work on something, pass it to another program work on it and so on. Each program also has an isolated location in the fs for persisting user data but since the only way for one program to access data from another program by the user explicitly sending it over, no application can access something it shouldn't have without the users interaction. So like iOS in that respect also. Of course the user can still be socially engineered into giving some data to a program that shouldn't have it but I don't think it could possibly be worse than what we have today.
There are a bunch of other problems and challenges also that I've not gotten around to consider, but I feel that an operating system like the one I described, if open source under an acceptable license (ISC, BSD, MIT or similar preferably) existed, I'd gladly throw away the portability advantages of POSIX in change for it.