But an important piece of advice is at the bottom of one of their pages [1]: "Avoid micro-optimizing your JavaScript". Apart from their argument there, keep in mind you are programming for a number of very different runtime environments. An optimization that gives you a big boost in one implementation may slow you down on another one. That is true not just between various vendors but also among runtime versions from the same vendor.
[0] https://developers.google.com/web/tools/chrome-devtools/eval...
[1] https://developers.google.com/web/fundamentals/performance/r...