I've overseen a few big Dynamo installations at this point, but for the most part I wouldn't store any "core" information in there (say like a customer, merchant, or product at Amazon) because after adding data to Dynamo, your ability to query and restructure it is quite limited. We've generally put data in that's append-only, is considerable in volume, and which we only ever need to retrieve in a few particular ways. To go back to the Amazon example, I probably wouldn't put a customer, merchant, or product in it, but I might put in a log entry for a purchase transaction.
What I'm trying to suss out is whether the sweet spot product like Citus is more akin to a Dynamo, or more akin to a traditional RDMS.