This is potentially about more than weight gain. The DNA-PK-mediated pathway they've discovered looks an awful lot like something you'd design to control senescence.
The DNA-PK inhibitor used, NU7441, is orally active and the press release even calls it drug-like. The human-equivalent dose based on bodyweight is about 3g/day (three pills worth). The actual HED is probably smaller. Currently very expensive.[1]