But how to distinguish this from absolute nonsense? Intuition is probably the number one thing -- what smells like BS? It's not a perfect substitute for objective knowledge, but I think as engineers and scientists, we undervalue our subjective life experiences in shaping our view. Also, it helps to have a discerning eye for the macroscopic message the author is trying to deliver. Many times, we tend to attack the articulation or delivery of a thought, and miss the underlying message. In the context of the author of that article was saying, we can all agree that we have a poor understanding of pharmaceuticals (SSRI's in particular), and it helps to stay with the feeling of depression to know what your body is trying to convey to you, rather than flood the body with more input to make the "negative" emotion leave. I took that thought and discarded all the other specifics -- because I don't expect anyone to be 100% right, and hence I take the kernel in each viewpoint and leave the husk.