One big thing that we're trying to do is make the users' profile pages more of a destination in themselves, where your account on cheezburger is where you express your sense of humor to the world and consume aggregated funny stuff from the people you care about.
A lot of people (myself included) use multiple social networks/online communities for different things. Personal example: Flickr is for my "serious" photos, I use tweetphoto for cameraphone snapshots and bestc.am for more artistic cameraphone creations.
Picture using Twitter for current friends and celebrities, Facebook for family and old high-school friends, and Cheezburger for your online humor friends. Naturally there's overlap (we support sharing your funny stuff on Facebook and Twitter) but we already have a growing number of people who use our (very simple) systems for friending and messaging.