We have antibiotics for plague, and vaccination / eradication for small pox. That doesn't feel like we evolved any resistance. A couple of thousand cases of plague are reported to WHO each year.
If you take into account the infection of native Americans compared to Europeans since the 15th to 19th century [0] you'd infer that some ethnic stratum really evolved a lot of resistance wrt. to smallpox.
Conversely, because of smallpox eradication I would guess that some part of the population probably regressed on that.
The spread of disease from European contact was not always accidental. Europeans arriving in the Americas had long been exposed to the diseases, attaining a measure of immunity, and thus were not as severely affected by them. Therefore, disease could be an effective biological weapon.
[0]: https://en.wikipedia.org/wiki/Native_American_disease_and_ep...
https://www.sciencedaily.com/releases/2005/03/050325234239.h...
While we're at it, I can't recall the last time I met an accidental pedant.