Employers are going to have a bias against you for not having a CS degree. That doesn't mean it's a deal breaker, however.

The biggest thing you can do is have a portfolio ready. Show potential employers that you are capable with a great website. Examples of projects you've done, and what you are capable of are going to be absolutely imparitive.

As far as minimal skill set, you are going to want be very confident/comfortable with HTML/CSS as well as cross browser quirks. Familiarity with Photoshop is a definite asset, as you will be required to chop graphics at a lot of shops. I would go to major job search sites, and look at the qualifications for front-end web developers. See what employers are really looking for right now and focus on that.