It's worth mentioning that libfaketime [1] is a more mature alternative with macOS support and more complete coverage of the relevant system calls. Nothing against the current project but that might be a better choice for many people.
If they're inspecting EHDR and calling VDSO directly, though, or they've statically compiled in their libc, then it won't help though.
I've also had a lot of issues getting it into tightly sandboxed contexts (e.g. the flash runtime in chrome).