Hard to imagine how they won't be profitable. The cost of providing the service is pennies and they get dollars per transaction.
If the answer is they need to raise prices and/or reduce the drivers' cut, how will they be better than the taxi services they're replacing? Many taxi services up here in Canada already have apps that are close to on par with what Uber offers.
pssst!! it's not a 'angelic ride sharing' service period. it's hiring taxi drivers and in this case mostly entrepreneurial taxi drivers having multiple cars and running it as a business.