Personally, yes - I like asking about high-level run-downs of a project on their resume. I then choose points to stop them (either randomly or if I know a lot about the subtopic) and dig deeper and see where their comfort level lies.

There are a lot of benefits to this approach:

1. Keeps the topic on something they are presumably comfortable with.

2. Gauges their seniority level: more senior folks can talk deeply about a wider variety of topics.

3. Tests their communication and explanation skills, again about a topic they should be comfortable with.

Some potential pitfalls:

1. Makes it harder to objectively compare candidates. I think this is impossible anyway, so I don't consider it a big deal.

2. Some candidates, especially junior ones, simply don't have many projects on their resume to talk about. In this case I'll often ask them to explain a skill or technology they are experienced with.

3. It's harder to conduct these interviews. Giving a problem and passively watching and helping as needed is a lot easier than keeping up an active dynamic conversation.