What are examples of legitimate use-cases for supporting custom cursors? If you're considering using a custom cursors, keep in mind that not all users keep the normal cursor size. At least on macOS, you can increase the size from the Accessibility panel.
Hopefully the web can start providing access to more built-in accessibility features. One such feature that was added recently is Reduced Motion Media Query [1]. Wouldn't it be great to have a media query for "Increase contrast"? I can't be the only one that's occasionally frustrated from websites that mix 50 shades of barely readable gray.
[0] https://developer.apple.com/library/content/documentation/Ap...
[1] https://developer.apple.com/library/content/releasenotes/Gen...