On Mac, one bug that bites me about once per week is the editor becomes unresponsive. Not the whole application, I can still focus on windows, use the menus, and scroll the text, but the text editor just goes vegetable. The caret disappears, and I am unable to select text, type, paste, etc. Occasionally it returns after 20-30 seconds, but usually I have to restart Sublime.
It's still a great application in spite of this bug, but it is annoying when it happens.